mRTVP-1, a Novel p53 Target Gene with Proapoptotic Activities

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mRTVP-1, a novel p53 target gene with proapoptotic activities.

We identified a novel mouse gene, mRTVP-1, as a p53 target gene using differential display PCR and extensive promoter analysis. The mRTVP-1 protein has 255 amino acids and differs from the human RTVP-1 (hRTVP-1) protein by two short in-frame deletions of two and nine amino acids. RTVP-1 mRNA was induced in multiple cancer cell lines by adenovirus-mediated delivery of p53 and by gamma irradiatio...

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ژورنال

عنوان ژورنال: Molecular and Cellular Biology

سال: 2002

ISSN: 0270-7306,1098-5549

DOI: 10.1128/mcb.22.10.3345-3357.2002